br In summary our study provides evidence that inflammatory
In summary, our study provides evidence that inflammatory markers may be used to predict frailty in a breast cancer BMPO about to undergo treatment, and may serve as clinically useful biomarkers.
Authors' Disclosures of Potential Conflicts of Interest
The authors have no relevant conflicts of interest to report.
Conception and design: Nikesha Gilmore, Allison Magnuson, Supriya Mohile, Michelle Janelsins.
Provision of study materials or participants: Michelle Janelsins, Sharon Cole, Benjamin T. Esparaz, Jeffrey K. Giguere. Statistical analysis: Nikesha Gilmore, Lianlian Lei.
Data analysis and interpretation: Nikesha Gilmore, Sindhuja Kadambi, Lianlian Lei, Kah Poh Loh, Mostafa Mohamed, Allison Magnuson, Supriya Mohile, Michelle Janelsins. Manuscript preparation: Nikesha Gilmore, Sindhuja Kadambi, Lianlian Lei, Supriya Mohile, Michelle Janelsins.
Final approval of manuscript: Nikesha Gilmore, Sindhuja Kadambi, Lianlian Lei, Kah Poh Loh, Mostafa Mohamed, Allison Magnuson, Sharon Cole, Benjamin T. Esparaz, Jeffrey K. Giguere, Supriya Mohile, Michelle Janelsins.
We wish to acknowledge Drs. Susan Rosenthal and Amber Kleckner for their editorial assistance.
Appendix A. Supplementary data
Supplementary data to this article can be found online at https://doi.
 Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clin-ical instrument to classify frailty in elderly people. Lancet 1999;353(9148):205–6.  Kojima G, Iliffe S, Jivraj S, Walters K. Association between frailty and quality of life among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health 2016;70(7):716–21.
 Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007;128(1):92–105.  Ventura MT, Casciaro M, Gangemi S, Buquicchio R. Immunosenescence in aging: between immune cells depletion and cytokines up-regulation. Clin Mol Allergy 2017;15:21.  Pallis AG, Hatse S, Brouwers B, Pawelec G, Falandry C, Wedding U, et al. Evaluating the physiological reserves of older patients with cancer: the value of potential biomarkers of aging? J Geriatr Oncol 2014;5(2):204–18.
 Lin Y, Kim J, Metter EJ, Nguyen H, Truong T, Lustig A, et al. Changes in blood lympho-cyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors. Immun Age 2016;13:24.  Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc 2007;55(6):864–71.  Puzianowska-Kuznicka M, Owczarz M, Wieczorowska-Tobis K, Nadrowski P, Chudek J, Slusarczyk P, et al. Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study. Immun Age 2016;13:21.  Van Epps P, Oswald D, Higgins PA, Hornick TR, Aung H, Banks RE, et al. Frailty has a stronger association with inflammation than age in older veterans. Immun Age 2016;13:27.
 Lippitz BE, Harris RA. Cytokine patterns in cancer patients: a review of the correlation between interleukin 6 and prognosis. Oncoimmunology 2016;5(5): e1093722.
 Janelsins MC, Mustian KM, Palesh OG, Mohile SG, Peppone LJ, Sprod LK, et al. Differ-ential expression of cytokines in breast cancer patients receiving different chemo-therapies: implications for cognitive impairment research. Support Care Cancer 2012;20(4):831–9.
 Ganz PA, Bower JE, Kwan L, Castellon SA, Silverman DH, Geist C, et al. Does tumor necrosis factor-alpha (TNF-alpha) play a role in post-chemotherapy cerebral dys-function? Brain Behav Immun 2013;30:S99–108 Suppl.
 Kesler S, Janelsins M, Koovakkattu D, Palesh O, Mustian K, Morrow G, et al. Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer sur-vivors. Brain Behav Immun 2013;30:S109–16 Suppl.