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Contents lists available at ScienceDirect
Current Problems in Cancer
journal homepage: www.elsevier.com/locate/cpcancer
Association of lymphadenectomy and survival in epithelial ovarian cancer
Ozlem Ercelep a,∗, Melike Ozcelik a, Mahmut Gumus b
a Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey b Department of Medical Oncology, Faculty of Medicine, Bezmi Alem Vakif University, Istanbul, Turkey
Purpose: Lymph node metastasis has a significant contribu-
Keywords: tion to the prognosis of epithelial ovarian cancer but the role
Lymphadenectomy of lymph node dissection in treatment is not clear. In this
Ovarian cancer study, we aimed to retrospectively determine the effect of
the number and localization of lymph nodes removed and
the number of metastatic lymph nodes on survival.
Methods: In this study, we retrospectively reviewed the data
of 378 patients (210 patients with lymph node dissection
and 168 patients with no dissection) who underwent pri-
mary surgery between 2004 and 2014 in various centers
with epithelial ovarian cancer diagnosis and followed up in
our medical oncology clinic. Demographic and histopatho-
logic features, stage, Ca 125 levels, chemotherapy responses
of these patients were examined and survival analyzes were
Results: The median age of the patients was 52 years (range
phadenectomy had significantly improved progression free
patients with >10 lymph nodes removed compared to pa-
✩ Compliance with ethical standards. Disclosure of potential conflicts of interest: None. Research involving human participants and/or animals: Not applicable because the study was retrospective.
∗ Correspondence to: Ozlem Ercelep, Department of Medical Oncology, Pendik Education and Research Hospital, Mar-mara University, Istanbul, Turkey.
E-mail address: [email protected] (O. Ercelep).
was found to be longer in patients with pelvic and paraaortic lymph node dissection compared to patients with only pelvic lymph node dissection (P < 0.05). Patients in stage I-II had no difference in PFS and OS. Patients in stage III-IV had no difference in PFS but there was a significant difference in OS (P = 0.02).
Conclusion: It may be a therapeutic effect of lymphadenec-tomy in advanced stage ovarian cancer. The number of lymph nodes removed and the removal of the paraaortic lymph nodes may also contribute to the treatment.