• 2019-07
  • 2019-08
  • 2019-09
  • 2019-10
  • 2019-11
  • 2020-03
  • 2020-07
  • 2020-08
  • R Hempelmann Optical and uorescence properties of


    R. Hempelmann, Optical and ßuorescence properties of MgO nanoparticles in micellar solution of hydroxyethyl laurdimonium chloride, Chem. Phys. Lett. 636 (2015) 26Ð30.
    [43] K. Saravanakumar, C. Yu, K. Dou, M. Wang, Y. Li, J. Chen, Synergistic effect of Trichoderma-derived antifungal metabolites and cell wall degrading enzymes on enhanced biocontrol of Fusarium oxysporum f. sp. Cucumerinum, Biol. Control 94 (2016) 37Ð46.
    [44] K. Saravanakumar, R. Vivek, N. Sithranga Boopathy, L. Yaqian, K. Kathiresan, J. Chen, Anticancer potential of bioactive 16-methylheptadecanoic UNC-1999 methyl ester derived from marine Trichoderma, J. Appl. Biomed. 13 (2015) 199Ð212. [45] K. Saravanakumar, S. Mandava, R. Chellia, E. Jeevithan, R.S. Babu Yelamanchi,
    D. Mandava, W. Wen-Hui, J. Lee, D.-H. Oh, K. Kathiresan, M.-H. Wang, Novel metabolites from Trichoderma atroviride against human prostate cancer cells and their inhibitory effect on Helicobacter pylori and Shigella toxin producing Escherichia coli, Microb. Pathog. 126 (2019) 19Ð26.
    [46] P.K. Seetharaman, R. Chandrasekaran, S. Gnanasekar, G. Chandrakasan, M. Gupta, D.B. Manikandan, S. Sivaperumal, Antimicrobial and larvicidal activity of eco-friendly silver nanoparticles synthesized from endophytic fungi Phomopsis liquidambaris, Biocatal. Agric. Biotechnol. 16 (2018) 22Ð30. [47] K. Saravanakumar, M.-H. Wang, Trichoderma based synthesis of anti-pathogenic silver nanoparticles and their characterization, antioxidant and cytotoxicity properties, Microb. Pathog. 114 (2018) 269Ð273. [48] K. Saravanakumar, D. MubarakAli, K. Kathiresan, N. Thajuddin, N.S. Alharbi, J. Chen, Biogenic metallic nanoparticles as catalyst for bioelectricity production: a novel approach in microbial fuel cells, Mater. Sci. Eng., B 203 (2016) 27Ð34. [49] K. Saravanakumar, S. Shanmugam, N.B. Varukattu, D. MubarakAli, K. Kathiresan, M.-H. Wang, Biosynthesis and characterization of copper oxide nanoparticles from indigenous fungi and its effect of photothermolysis on human lung carcinoma, J. Photochem. Photobiol., B 190 (2019) 103Ð109.
    [50] V. Srivastava, Y.C. Sharma, M. SillanpŠŠ, Green synthesis of magnesium oxide nanoßower and its application for the removal of divalent metallic species from synthetic wastewater, Ceram. Int. 41 (2015) 6702Ð6709. [51] G. Sharma, R. Soni, N.D. Jasuja, Phytoassisted synthesis of magnesium oxide nanoparticles with Swertia chirayaita, J. Taibah Univ. Sci. 11 (2017) 471Ð477. [52] L. Jianping, Q. Longzhen, Q. Baojun, Controlled synthesis of magnesium hydroxide nanoparticles with different morphological structures and related properties in ßame retardant ethyleneÐvinyl acetate blends, Nanotechnology 15 (2004) 1576.
    [57] R. Sriranjani, B. Srinithya, V. Vellingiri, P. Brindha, S.P. Anthony, A. Sivasubramanian, M.S. Muthuraman, Silver nanoparticle synthesis using Clerodendrum phlomidis leaf extract and preliminary investigation of its antioxidant and anticancer activities, J. Mol. Liq. 220 (2016) 926Ð930.
    [58] J.R. Nakkala, R. Mata, S.R. Sadras, Green synthesized nano silver: synthesis, physicochemical proÞling, antibacterial, anticancer activities and biological in vivo toxicity, J. Colloid Interface Sci. 499 (2017) 33Ð45.
    [59] S. Rajeshkumar, C. Malarkodi, M. Vanaja, G. Annadurai, Anticancer and enhanced antimicrobial activity of biosynthesizd silver nanoparticles against clinical pathogens, J. Mol. Struct. 1116 (2016) 165Ð173. [60] K. Satyavani, S. Gurudeeban, T. Ramanathan, T. Balasubramanian, Toxicity study of silver nanoparticles synthesized from suaeda monoica on Hep-2 cell line, Avicenna J. Med. Biotechnol. 4 (2012) 35Ð39. 
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    Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer T metastasis inhibition
    Hao Yea, Kaiyuan Wanga, Menglin Wanga, Rongzheng Liua, Hang Songb, Na Lia, Qi Lua, Wenjuan Zhanga, Yuqian Dua, Wenqian Yanga, Lu Zhonga, Yu Wanga, Bohong Yub, Hong Wangb, Qiming Kanc, Haotian Zhangc, Yongjun Wanga, Zhonggui Hea,∗∗, Jin Suna,∗ a Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China
    b College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China
    c School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, PR China
    P-Selectin and CD44
    Breast cancer metastasis
    Platelet membrane 
    Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photo-chemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NPs), referred to as nanoplatelets. A chemotherapeutic drug, doxorubicin (DOX), and an FDA-approved photothermal agent, indocyanine green (ICG), are co-encapsulated into the biomimetic nanoplatelets. Nanoplatelets possess immune surveillance-escaping capability and specifically capture and clear CTCs in both blood and lymphatic circulations via high-affinity interactions between the P-Selectin of PM and CD44 receptors of tumor cells. PM-coated NPs show greater cellular uptake in MDA-MB-231 breast cancer cells and further elicit higher cytotoxicity to tumor cells relative to uncoated NPs. In vivo, we disclose that the multifunctional nanoplatelets not only completely ablate the primary tumor but also inhibit breast cancer metastasis with high efficiency in the three established xenograft or orthotopic breast tumor-bearing mice models. We conclude that such biomimetic nanoplatelets represent a promising strategy of coating a surface of nanoparticles with platelet membrane to actively capture and destroy CTCs in blood and lymph in breast cancer anti-metastasis therapy.