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  • br Anxiety and depression HAD br The mean

    2020-08-18


    3.4. Anxiety and depression (HAD)
    The mean anxiety scores reported by women with cancer at the one-year and long-term assessment were 5.0 (SD 4.1) and 6.2 (SD 4.3), respectively. Corresponding figures for women without cancer at one-year and long-term were 4.2 (SD 3.7) and 4.5 (SD 4.3). The mean depression scores reported by women with cancer at one-year and long-term were 2.1 (SD 2.3) and 3.1 (SD 3.2), respec-tively, while it BYL719 was 1.9 (SD 2.5) and 2.6 (SD 3.0) for women without cancer at one-year and long-term, respectively. There was a sta-tistical significant increase in depression score when comparing long-term- with one-year-scores for women without cancer (p ¼ 0.042). No significant between-group difference was observed at the long-term assessment.
    There was a statistical significant decrease in ‘General health’ at the long-term assessment versus one year post-RRM for both groups (p 0.05), Table 3. There were no between-group differ-ences in HRQoL at the long-term assessment.
    4. Discussion
    This is, to our knowledge, the furthermost prospective long-
    Table 2
    Satisfaction of results after breast reconstruction (EORTC QLQ-BRR26): mean and standard deviation (SD) for all women responding at the long-term assessment; unadjusted and adjusted mean differences (MD) between women with and without previous breast cancer.
    Long-term assessment
    Unadjusted mean difference
    Adjusteda mean difference
    Parameter
    Sexuality
    Cosmetic outcome breast b
    Cosmetic outcome donor site
    S
    Range 0e100, where higher scores indicate higher satisfaction for ‘Satisfaction with reconstructed nipple’ and ‘Cosmetic outcome of breast’, and vice versa for the rest of the measures.
    S Small and M moderate clinical significant differences [26]. a Adjusted for age at long-term follow-up, time since risk-reducing surgery, mutation, bilateral prophylactic salpingo-oophorectomy, and body mass index (BMI; kg/m2). b Too few observations: n ¼ 9e12. c Too few observations: n ¼ 16e21.
    Dissatisfied with body
    Dissatisfied with body
    Dissatisfied with scar(s)
    Dissatisfied with scar(s)
    Body less whole
    Body less whole
    Avoid people
    Avoid people
    Less sexually attractive
    Less sexually attractive
    Difficult to see oneself naked
    Difficult to see oneself naked
    Less feminine
    Less feminine
    Dissatisfied with appearance
    Dissatisfied with appearance
    Less physically attractive
    Less physically attractive
    Self-consciousness
    Self-consciousness
    (Cancer, long-term) Little to very much
    (Cancer, 1 year) Little to very much (No cancer, long-term) Little to very much
    (No cancer, 1 year) Little to very much
    Fig. 2. Body Scale Image (BIS): percentage of women with and without previous breast cancer reporting ‘little’ to ‘very much’-body image problems at the one year and long-term assessment after the risk-reducing breast surgery with immediate breast reconstruction. The y-axis illustrates the ten items included in the BIS. The data is anabolic reactions presented in terms of proportions (%) of women responding at each time of assessment, where n(cancer, 1 year) ¼ 35, n(cancer, long-term) ¼ 46e47, n(no cancer, 1 year) ¼ 69e70, and n(no cancer, long-term) ¼ 98e99.
    term follow-up study about psychosocial outcomes for women with increased hereditary risk for breast cancer post-RRM and IBR. HRQoL, anxiety/depressive symptoms appeared to remain rather unchanged in the long-term, with one exception. ‘General health’ decreased over time in both groups. Body image problems noted at 
    the one-year assessment did not change at the long-term assess-ment, and there were no differences between the groups, except from improved self-consciousness over time for women without breast cancer, and significantly increased ‘Sexual discomfort’ over time for women with breast cancer.
    Table 3
    Sexual activity e pleasure and discomfort subscales, and habit item (SAQ), and Health-related quality of life (SF-36): mean and standard deviation (SD) at one year and long-term for all respondents at each assessment point, and for women responding at both occasions; long-term changes in sexual activity and health-related quality of life compared with one year after risk-reducing surgery for women with and without previous breast cancer.
    Women responding at each
    Difference over time Women responding at both assessments
    assessment
    Cancer No cancer
    Cancer
    No cancer
    One year Long- One year Long-
    One year Long- Difference (95% p One year Long- Difference (95% p
    term
    term
    term CI)
    term CI)
    Mean Mean Mean Mean
    Mean Mean
    Mean