br Anxiety and depression HAD br The mean

3.4. Anxiety and depression (HAD)
The mean anxiety scores reported by women with cancer at the one-year and long-term assessment were 5.0 (SD 4.1) and 6.2 (SD 4.3), respectively. Corresponding figures for women without cancer at one-year and long-term were 4.2 (SD 3.7) and 4.5 (SD 4.3). The mean depression scores reported by women with cancer at one-year and long-term were 2.1 (SD 2.3) and 3.1 (SD 3.2), respec-tively, while it BYL719 was 1.9 (SD 2.5) and 2.6 (SD 3.0) for women without cancer at one-year and long-term, respectively. There was a sta-tistical significant increase in depression score when comparing long-term- with one-year-scores for women without cancer (p ¼ 0.042). No significant between-group difference was observed at the long-term assessment.
There was a statistical significant decrease in ‘General health’ at the long-term assessment versus one year post-RRM for both groups (p 0.05), Table 3. There were no between-group differ-ences in HRQoL at the long-term assessment.
4. Discussion
This is, to our knowledge, the furthermost prospective long-
Table 2
Satisfaction of results after breast reconstruction (EORTC QLQ-BRR26): mean and standard deviation (SD) for all women responding at the long-term assessment; unadjusted and adjusted mean differences (MD) between women with and without previous breast cancer.
Long-term assessment
Unadjusted mean difference
Adjusteda mean difference
Parameter
Sexuality
Cosmetic outcome breast b
Cosmetic outcome donor site
S
Range 0e100, where higher scores indicate higher satisfaction for ‘Satisfaction with reconstructed nipple’ and ‘Cosmetic outcome of breast’, and vice versa for the rest of the measures.
S Small and M moderate clinical significant differences [26]. a Adjusted for age at long-term follow-up, time since risk-reducing surgery, mutation, bilateral prophylactic salpingo-oophorectomy, and body mass index (BMI; kg/m2). b Too few observations: n ¼ 9e12. c Too few observations: n ¼ 16e21.
Dissatisfied with body
Dissatisfied with body
Dissatisfied with scar(s)
Dissatisfied with scar(s)
Body less whole
Body less whole
Avoid people
Avoid people
Less sexually attractive
Less sexually attractive
Difficult to see oneself naked
Difficult to see oneself naked
Less feminine
Less feminine
Dissatisfied with appearance
Dissatisfied with appearance
Less physically attractive
Less physically attractive
Self-consciousness
Self-consciousness
(Cancer, long-term) Little to very much
(Cancer, 1 year) Little to very much (No cancer, long-term) Little to very much
(No cancer, 1 year) Little to very much
Fig. 2. Body Scale Image (BIS): percentage of women with and without previous breast cancer reporting ‘little’ to ‘very much’-body image problems at the one year and long-term assessment after the risk-reducing breast surgery with immediate breast reconstruction. The y-axis illustrates the ten items included in the BIS. The data is anabolic reactions presented in terms of proportions (%) of women responding at each time of assessment, where n(cancer, 1 year) ¼ 35, n(cancer, long-term) ¼ 46e47, n(no cancer, 1 year) ¼ 69e70, and n(no cancer, long-term) ¼ 98e99.
term follow-up study about psychosocial outcomes for women with increased hereditary risk for breast cancer post-RRM and IBR. HRQoL, anxiety/depressive symptoms appeared to remain rather unchanged in the long-term, with one exception. ‘General health’ decreased over time in both groups. Body image problems noted at 
the one-year assessment did not change at the long-term assess-ment, and there were no differences between the groups, except from improved self-consciousness over time for women without breast cancer, and significantly increased ‘Sexual discomfort’ over time for women with breast cancer.
Table 3
Sexual activity e pleasure and discomfort subscales, and habit item (SAQ), and Health-related quality of life (SF-36): mean and standard deviation (SD) at one year and long-term for all respondents at each assessment point, and for women responding at both occasions; long-term changes in sexual activity and health-related quality of life compared with one year after risk-reducing surgery for women with and without previous breast cancer.
Women responding at each
Difference over time Women responding at both assessments
assessment
Cancer No cancer
Cancer
No cancer
One year Long- One year Long-
One year Long- Difference (95% p One year Long- Difference (95% p
term
term
term CI)
term CI)
Mean Mean Mean Mean
Mean Mean
Mean