• The nutrient sensing pathway that encompasses the dynamic an

  2019-07-06

  

  The nutrient-sensing pathway that encompasses the dynamic and reversible post-translational modification called O-linked-β-N-acetylglucosaminylation (O-GlcNAcylation) plays a significant role in disease progression. In fact, O-GlcNAcylation of nuclear, cytoplasmic and mitochondrial target proteins i

• Inducible nitric oxide synthase iNOS is regarded as a

  2019-07-05

  

  Inducible nitric oxide synthase (iNOS) is regarded as a principal mediator of NO-dependent S-nitrosylation [24]. However, more investigations are needed to understand the expression of iNOS and the subsequent S-nitrosylation of important proteins in endothelial dysfunction. Several studies have show

• In addition to phosphorylation tau has also been shown

  2019-07-05

  

  In addition to phosphorylation, tau has also been shown to undergo acetylation [14,15,74]. Acetylation occurs when the acetyl-coenzyme A transfers an acetyl group to the ε-amino group of a lysine residue of a target protein [73]. This PTM is reversible and catalyzed by histone acetyl transferases (H

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